3 edition of Biology of the epithelial lens cells in relation to development, aging and cataract = found in the catalog.
Biology of the epithelial lens cells in relation to development, aging and cataract =
by Editions de l"Institut national de la santé et de la recherche médicale in Paris
Written in English
|Other titles||Biologie du cristallin au cours du developpement et de la senescence.|
|Statement||edité sous la responsabilité de = edited by, Yves Courtois et Franc̜ois Regnault.|
|Series||Colloques et seminaires technologiques ;, vol. 60, Colloques de l"Institut national de la santé et de la recherche médicale ;, no 60.|
|Contributions||Courtois, Yves., Regnault, François, 1933-, Institut national de la santé et de la recherche médicale (France)|
|LC Classifications||QP478 .B56 1976|
|The Physical Object|
|Pagination||299 p. :|
|Number of Pages||299|
|LC Control Number||82141871|
The eye's lens contains so-called epithelial stem cells, which generate replacement lens cells throughout life -- though that declines with aging, according to Zhang. During traditional cataract surgery, most of those stem cells are removed, Zhang explained. So, his team developed a less invasive approach that preserves the lens "capsule," a. INTRODUCTION. The lens consists of a monolayer of epithelial cells at the anterior face of the organ and highly elongated, crystallin-rich fiber cells that differentiate from these epithelial cells at a region of the lens termed the lens equator (Cvekl and Ashery-Padan, ).The lens is encased by the acellular lens capsule, which is the thickest basement membrane in the body.
Li WC. Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. J Cell Biol. ;– Lu B, et al. miR regulates the antioxidant function of lens epithelial cells affected by age-related cataracts. Int J . Peroxide resistance in human and mouse lens epithelial cell lines is related to long-term changes in cell biology and architecture Free Radical Biology and Medicine, Vol. 39, No. 6 Calcium-activated RAF/MEK/ERK Signaling Pathway Mediates pdependent Apoptosis and Is Abrogated by αB-Crystallin through Inhibition of RAS Activation.
Peroxide resistance in human and mouse lens epithelial cell lines is related to long-term changes in cell biology and architecture Free Radical Biology and Medicine, Vol. 39, No. 6 Age-related nuclear cataract—oxidation is the key. Teri M.S. Greiling, John I. Clark, in International Review of Cell and Molecular Biology, Lens capsule. The human lens capsule is the thickest basement membrane in the body and a vital component of a functional lens. Like other basement membranes, the lens capsule is composed of a three-dimensional matrix of type IV collagen, laminin, perlecan, nidogen, fibronectin, and SPARC as well.
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This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation to and in the development of posterior capsular opacification (PCO). PCO remains the most common long-term complication of modern cataract surgery, occurring months or years after cataract surgery, unlike most other complications.
Get this from a library. Biology of the epithelial lens cells in relation to development, aging and cataract = Biologie du cristallin au cours du developpement et de la senescence: colloque, Paris, mars [Yves Courtois; François Regnault; Institut national de.
Title(s): Biology of the epithelial lens cells in relation to development, aging and cataract = Biologie du cristallin au cours du dévelopment et de la sénescence, Paris, mars colloque/ édité sous la responsabilité de Yves Courtois et François Regnault.
Country of Publication: France Publisher: Paris: INSERM, c The lens is a transparent, avascular tissue whose function is to focus light onto the retina (Bassnett et al., ).The adult lens is encapsulated and consists of a monolayer of cuboidal epithelial cells on the anterior surface that overlie layers of fiber cells formed by differentiation of epithelial cells at the lens equator that elongate Cited by: Continued.
The eye's lens contains so-called epithelial stem cells, which generate replacement lens cells throughout life -- though that declines with aging, according to Zhang.
During. The ocular lens is a model system for understanding important aspects of embryonic development, such as cell specification and the spatiotemporally controlled formation of a three-dimensional structure.
The lens, which is characterized by transparency, refraction and elasticity, is composed of a bulk mass of fiber cells attached to a sheet of lens epithelium. Although lens induction has been. Cataract is a visible opacity in aging and cataract = book lens substance, which, when located on the visual axis, leads to visual loss.
Age-related cataract is a cause of blindness on a global scale involving genetic and environmental influences. With ageing, lens proteins. In a recent study, researchers have explored senescence-related proteins and protein interactions in cataracts, a leading cause of visual impairment and blindness in older adults.
Cataracts are characterized by the clouding of the lens in the eye, which leads to impaired vision. Cataracts generally develop slowly and can affect either one or both eyes at the same time. Congenital cataract. The incidence of congenital or infantile cataracts has been estimated to be about 72 perchildren, with estimates varying from 12 to and being generally higher in less-developed countries ().Hereditary cataracts usually account for between % and 25% of congenital cataracts (11–13).Congenital cataracts may occur as isolated defects or may be associated with.
Hongyan Ge's 20 research works with citations and reads, including: A novel silent mutation E83E of αA-crystallin in age-related cataract with impaired chaperone function. eye lens and cataract disease The ocular lens is responsible for the ﬁne focusing of light onto the retina, and its transparency is vital for visual acuity (Figure 1a).
The lens anterior is lined with a single layer of epithelial cells, overlaying the lens cortex and nucleus, both of which are composed of elongated ﬁber cells.
Apoptosis and oxidative stress are the main etiology of age related cataract (ARC). This article aims to investigate the role of WRN in lens epithelial cells (LECs). We estimated the methylation level of WRN in anterior lens capsule tissues of ARC patients.
SRA01/04 (LECs) cells were treated with H2O2 or combined with 5-azadeoxycytidine (5-Aza-CdR) or chloroquine. INTRODUCTION. During development, the lens placode delaminates from the epidermal ectoderm and forms the lens vesicle.
In the lens vesicle, posterior epithelial cells differentiate into lens fiber cells, whereas anterior epithelial cells are retained as proliferative lens progenitor cells (Bassnett et al., ; Lovicu and McAvoy, ).In zebrafish, a lens mass without a vesicle delaminates.
UV light exposure of lens epithelial cells is associated with apoptosis of lens epithelial cells (21,22,(27)(28)(29) and human cataract formation (); however, the mechanisms used by lens. Interestingly, acetyl superoxide dismutase 2 (AcSOD2) levels were significantly higher in DM patients’ lens epithelial cells (LECs), whereas AMPKT phosphorylation was significantly increased in non-DM patients.
This indicates that AMPKT might be related to superoxide reduction and diabetic cataract. This gene encodes an eye lens-specific protein (19kDa) found at the junctions of lens fiber cells, where it may contribute to cell junctional organization.
It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation.
Similarly, crystallins are abundant in the cytoplasm of highly elongated fiber cells in the vertebrate lens and in lens epithelial cells (Delaye and Tardieu, ;Horwitz et al., ; Andley et.
markers, key lens regulatory genes and structural genes during lens development from iPS and ES cells. Our results demonstrate that patient–specific iPSCs can be used to generate lens cells efficiently.
Materials and Methods Cell culture Human lens epithelial cells were isolated from age-related cataract patients at the Eye and ENT Hospital. The outer edge of the lens consists of a single layer of epithelial cells, and a membrane that covers the entire organ [Kuszak ].
Lens epithelial cells do not divide except when undergoing repair. Some epithelial cells lose their nuclei and other organelles, and become lens fiber cells. This study suggests that: (1) ZA/AB located at the apices of lens epithelial cells may play a crucial role in the early stages of lens morphogenesis (e.g.
lens vesicle formation); (2) ZA/AB of. The new lens enlarges to normal size by the continuing division of anterior lens epithelial cells and their differentiation into lens fibers at the lens equator. Transcription factors important for lens fiber differentiation are Prox-1, Pax-6, Sox 1, Sox-2, Six-3, and MafB.
All are expressed only in dorsal iris PECs (Fig. ).This study demonstrates that osmoregulation impairment leads to the lens being susceptible to AR-mediated osmotic stress and eventually, cataract formation.
Overproduction of AKR1B1 and RAGE also plays a major role in diabetic cataract development. However, it is not yet known whether diabetic cataracts are related to lens epithelial cell EMT.Lens fiber cells are generated throughout life via continuous proliferation and differentiation of epithelial cells.
Differentiation of lens cells involves dramatic metabolic, morphologic, and functional changes in cellular components. Using an in vitro differentiation model, we demonstrated that the ubiquitinating activity increases during the early stage (proliferating phase) of bFGF-induced.